Ten fire engines and around 70 firefighters have been called to a fire at an old coal depot in Tavistock Road in West Drayton.
A container, an industrial conveyor belt, 15 vans and three articulated lorries are currently alight.
Station Manager Jon Holt, who is at the scene, said: “The fire is very visible and is producing a lot of smoke. Residents and businesses in the area should keep their windows and doors shut and drivers should avoid the area if possible.”
The Brigade’s 999 control officers have taken more than 55 calls to the fire. Around 15 people left the yard before the arrival of the Brigade. There are no reports of any injuries.
The Brigade was called at 2.15pm Fire crews from Hillingdon, Heathrow, Feltham and other surrounding fire stations are at the scene.
The cause of the fire is not known at this stage.